Criminal Minds on Diabetes

From this week’s episode of Criminal Minds, “The Uncanny Valley”:

“Diabetics metabolize everything they consume differently.  Food, drink, drugs … it all gets broken down into blood sugar.”

Ignoring the fact that not all food and drink gets broken into blood sugar (Coke Zero, anyone?), you’re telling me my drugs all turn into blood sugar too?  Guess I’d better start taking insulin with my cholesterol pills from now on.

The show also asserts that diabetics can metabolize drugs faster, and thus our victim could shake off the paralytic.  (Which was being received via an I.V. drip.)  This struck me at first as either poorly researched or poorly explained.

So I spent this morning digging up research so as not to come off as an idiot when I wrote my rant, and what do you know.  I came across a 2007 study from The National Institute of Diabetes and Digestive and Kidney Diseases which states:

In fact, type 1 diabetes not only leads to activation of drug metabolic genes, but also has a profound effect on the metabolism of certain drugs. Mice with induced type 1 diabetes rapidly clear their systems of a compound that induces temporary paralysis, while normal mice cannot.

From that same article, “Controlling the diabetes reversed the effect: when insulin was given to the mice, the CAR-induced genes turned off. “  So in theory, since this woman was off her insulin, there might have been a window where she would have thrown off the effects of the drugs before falling into a diabetic coma.

I’m not finding anything to support the idea that drugs all break down into blood sugar, though.  That one still strikes me as goblin dung.  According to the article above, a diabetic with out-of-control glucose doesn’t clear the drug by breaking it down into sugar, but because (in mice, at least) this activates certain genes that clear the drug from the system.

So, I’m cranky about the “Everything turns into sugar” bit, but it looks like they did the research on the rest.  Thanks for that, Criminal Minds — the widespread laziness and misinformation spread in most books and shows when it comes to diabetes is a huge peeve of mine.

On that note, if any of my writer friends are ever doing a story that includes diabetes and have questions, please don’t hesitate to ask.  I’m not a doctor, but I can give you the basics and tell you what it’s like to live with the damn disease.

Also, I think I have a man-crush on Dr. Reid.